On-orbit assembly using superquadric potential fields

The autonomous on-orbit assembly of a large space structure is presented using a method based on superquadric artificial potential fields. The final configuration of the elements which form the structure is represented as the minimum of some attractive potential field. Each element of the structure is then considered as presenting an obstacle to the others using a superquadric potential field attached to the body axes of the element. A controller is developed which ensures that the global potential field decreases monotonically during the assembly process. An error quaternion representation is used to define both the attractive and superquadric obstacle potentials allowing the final configuration of the elements to be defined through both relative position and orientation. Through the use of superquadric potentials, a wide range of geometric objects can be represented using a common formalism, while collision avoidance can make use of both translational and rotation maneuvers to reduce total maneuver cost for the assembly process

Coupled orbit and attitude dynamics of a reconfigurable spacecraft with solar radiation pressure

This work investigates the orbital and attitude dynamics of future reconfigurable multi-panel solar sails able to change their shape during a mission. This can be enabled either by changing the relative position of the individual panels, or by using articulated mechanisms and deployable, retractable and/or inflatable structures. Such a model introduces the concept of modular spacecraft of variable morphology to large gossamer spacecraft. However, this joint concept is complex in nature and requires equations for coupled orbit/attitude dynamics. Therefore, as a starting point, the system is modelled as a rigid-body dumbbell consisting of two tip masses connected by a rigid, massless panel. The system is subjected to a central gravitational force field under consideration of solar radiation pressure forces. Therefore, we assign reflectivity coefficients to the tip masses and a high area-to-mass ratio. An analytical Hamiltonian approach is used to describe the planar motion of the system in Sun-centred Keplerian and non-Keplerian circular orbits. The stability and controllability of the system is enabled through changing the reflectivity coefficients, for example through the use of electro-chromic coating on its surface. The creation of artificial unstable equilibria of the system due to the presence of solar radiation pressure and heteroclinic connections between the equilibria are investigated. We further derive a constraint for the solar radiation pressure forces to maintain the system on a circular Sun-centred orbit. It is planned that the structure is eventually capable of reconfiguring between the equilibria by a minimum actuation effort

Shape-changing solar sails for novel mission applications

In order to increase the range of potential mission applications of solar sail technology, this paper introduces the concepts of shape change and continuously variable optical properties to large gossamer spacecraft. Merging the two concepts leads to the idea of solar sails as multi-functional platforms that can have potential benefits over conventional solar sails by delivering additional key mission functions such as power collection, sensing and communications. To this aim, the paper investigates the static deflection of a thin inelastic circular sail film with a variable surface reflectivity distribution. The sail film is modelled as a single surface framed by a rigid supporting hoop structure. When changing the reflectivity coefficient across the sail surface, the forces acting on the sail can be controlled without changing the incidence angle relative to the Sun. In addition, by assigning an appropriate reflectivity function across the sail, the load distribution due to solar radiation pressure can also be manipulated to control the billowing of the film. By an appropriate choice of reflectivity across the sail, specific geometries can be generated, such as a parabolic reflector, thus enabling a multi-functional sail. This novel concept of optical reconfiguration can potentially extend solar sail mission applications

Evaluating Feature Extraction Methods for Biomedical Word Sense Disambiguation

Evaluating Feature Extraction Methods for Biomedical WSD Clint Cuffy, Sam Henry and Bridget McInnes, PhD Virginia Commonwealth University, Richmond, Virginia, USA Introduction. Biomedical text processing is currently a high active research area but ambiguity is still a barrier to the processing and understanding of these documents. Many word sense disambiguation (WSD) approaches represent instances of an ambiguous word as a distributional context vector. One problem with using these vectors is noise -- information that is overly general and does not contribute to the word’s representation. Feature extraction approaches attempt to compensate for sparsity and reduce noise by transforming the data from high-dimensional space to a space of fewer dimensions. Currently, word embeddings [1] have become an increasingly popular method to reduce the dimensionality of vector representations. In this work, we evaluate word embeddings in a knowledge-based word sense disambiguation method. Methods. Context requiring disambiguation consists of an instance of an ambiguous word, and multiple denotative senses. In our method, each word is replaced with its respective word embedding and either summed or averaged to form a single instance vector representation. This also is performed for each sense of an ambiguous word using the sense’s definition obtained from the Unified Medical Language System (UMLS). We calculate the cosine similarity between each sense and instance vectors, and assign the instance the sense with the highest value. Evaluation. We evaluate our method on three biomedical WSD datasets: NLM-WSD, MSH-WSD and Abbrev. The word embeddings were trained on the titles and abstracts from the 2016 Medline baseline. We compare using two word embedding models, Skip-gram and Continuous Bag of Words (CBOW), and vary the word vector representational lengths, from one-hundred to one-thousand, and compare differences in accuracy. Results. The overall outcome of this method demonstrates fairly high accuracy at disambiguating biomedical instance context from groups of denotative senses. The results showed the Skip-gram model obtained a higher disambiguation accuracy than CBOW but the increase was not significant for all of the datasets. Similarly, vector representations of differing lengths displayed minimal change in results, often differing by mere tenths in percentage. We also compared our results to current state-of-the-art knowledge-based WSD systems, including those that have used word embeddings, showing comparable or higher disambiguation accuracy. Conclusion. Although biomedical literature can be ambiguous, our knowledge-based feature extraction method using word embeddings demonstrates a high accuracy in disambiguating biomedical text while eliminating variations of associated noise. In the future, we plan to explore additional dimensionality reduction methods and training data. [1] T. Mikolov, I. Sutskever, K. Chen, G. Corrado and J. Dean, Distributed representations of words and phrases and their compositionality, Advances in neural information processing systems, pp. 3111-3119, 2013.https://scholarscompass.vcu.edu/uresposters/1278/thumbnail.jp

Instability of fixed, low-thrust drag compensation

FORCED drag compensation using continuous low-thrustpropulsion has been considered for satellites in low Earth orbit. This simple, but nonoptimal, scheme merely requires that the thrust vector is directed opposite to the drag vector and that the magnitude of the two are equal. In principle, the drag force acting on the spacecraft could be determined onboard using accurate accelerometers. However, for small, low-cost spacecraft such sensors may beunavailable. An alternative strategy would be to Ž x the thrust magnitude equal to the expected air drag that would be experienced by the spacecraft. The thrust levelwould be periodically updated based on ground-based orbit determination. In this Engineering Note, it is shown that such a forced circular orbit with a Ž fixed thrust levelis exponentially unstable for all physically reasonable atmosphere models

What is the Economic Cost of Overweight Children?

Childhood overweight is now considered the most common health problem for children in the U.S. An important question is whether parents and policymakers will see rising medical expenditures for these children while they are still young. We estimate the overweight attributable fraction (OAF) of children’s medical expenditures, controlling for other factors that may cause expenditures to differ. We find that medical expenditures for overweight children are on average $12.09 higher per year (OAF = 0.5 percent), but confidence intervals are large and include zero. We also find little difference in the types of principal diagnoses per visit reported by weight status.

Cosmology: a bird's eye view

In this essay we discuss the difference in views of the Universe as seen by two different observers. While one of the observers follows a geodesic congruence defined by the geometry of the cosmological model, the other observer follows the fluid flow lines of a perfect fluid with a linear equation of state. We point out that the information these observers collect regarding the state of the Universe can be radically different; while one observes a non-inflating ever-expanding ever-lasting universe, the other observer can experience a dynamical behaviour reminiscent to that of quintessence or even that of a phantom cosmology leading to a 'big rip' singularity within finite time (but without the need for exotic forms of matter).Comment: 5 pages; received an honorable mention in the Gravity Research Foundation Essay Competition, 200

Parallel spinors and holonomy groups

In this paper we complete the classification of spin manifolds admitting parallel spinors, in terms of the Riemannian holonomy groups. More precisely, we show that on a given n-dimensional Riemannian manifold, spin structures with parallel spinors are in one to one correspondence with lifts to Spin_n of the Riemannian holonomy group, with fixed points on the spin representation space. In particular, we obtain the first examples of compact manifolds with two different spin structures carrying parallel spinors.Comment: 10 pages, LaTeX2

Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures

Objective To describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters. Design Prospective, open-label, long-term mechanism of action study. Setting University clinic. Methods MTX was initiated at a single weekly oral dose of 7.5 mg and dose adjusted for efficacy and toxicity for the duration of the study. Standard measures of disease activity were performed at baseline and every 6–36 months. Serum cytokine measurements in blood together with lymphocyte surface immunophenotypes and stimulated peripheral blood mononuclear cell (PBMC) cytokine production were assessed at each clinical evaluation. Results Cytokine concentrations exhibited multiple significant correlations with disease activity measures over time. The strongest correlations observed were for interleukin (IL)-6 (r=0.45, p<0.0001 for swollen joints and r=0.32, p=0.002 for tender joints) and IL-8 (r=0.25, p=0.01 for swollen joints). Significant decreases from baseline were observed in serum IL-1B, IL-6 and IL-8 concentrations. The most significant changes were observed for IL-6 (p<0.001). Significant increases from baseline were observed in IL-2 release from PBMCs ex vivo (p<0.01). In parallel, multiple statistically significant correlations were observed between MTX PKC measures and immune parameters. The change in swollen joint count correlated inversely with the change in area under the curve (AUC) for MTX (r=−0.63, p=0.007). Conclusions MTX therapy of patients with RA is accompanied by a variety of changes in serum cytokine expression, which in turn correlate strongly with clinical disease activity and MTX pharmacokinetics (PKCs). These data strongly support the notion that MTX mediates profound and functionally relevant effects on the immunological hierarchy in the RA lesion